Efficient TCT-catalyzed Synthesis of 1,5-Benzodiazepine Derivatives under Mild Conditions
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چکیده
منابع مشابه
Efficient TCT-catalyzed synthesis of 1,5-benzodiazepine derivatives under mild conditions.
2,4,6-Trichloro-1,3,5-triazine (TCT) efficiently catalyzed the condensation reactions between 1,2-diamines and various enolizable ketones to afford 1,5-benzodiazepines in good to excellent yields. Simple and mild reaction conditions, the use of a cheap catalyst and easy workup and isolation are notable features of this method.
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Silica sulfuric acid is found to catalyze efficiently the condensation of o-phenylenediamines with various linear and cyclic ketones to afford the corresponding 1,5-benzodiazepines in quantitative yields under solvent-free conditions at room temperature
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silica sulfuric acid is found to catalyze efficiently the condensation of o-phenylenediamines with various linear and cyclic ketones to afford the corresponding 1,5-benzodiazepines in quantitative yields under solvent-free conditions at room temperature
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The unique chemical properties of aryl trifluoromethyl sulfides (ArSCF3) have been known for over 60 years.[1] The capacity of SCF3 to act as a lipophilic electron-withdrawing group has resulted in the incorporation of ArSCF3 components into a number of pharmaceutical and agrochemical agents.[2] Unfortunately, direct access to this important class of compounds is complicated by a lack of effici...
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ژورنال
عنوان ژورنال: Molecules
سال: 2008
ISSN: 1420-3049
DOI: 10.3390/molecules13092313